Our laboratory’s main interest is to decipher the role of the Ca2+-dependent phosphatase calcineurin in memory and learning under physiologic and pathological conditions. To tackle this fundamental question, we study two prominent Lewy Body Pathologies: Dementia with Lewy Bodies (DLB) and in Parkinson’s Disease Dementia (PDD). We focus on a handful of calcineurin substrates that we have retrieved from unbiased phosphoproteomic approaches and we take multidisciplinary approaches that range from biophysical, biochemical to cell biological techniques in systems that span from yeast, to primary hippocampal and cortical rodent neurons, human iPSC-derived cortical neurons to in vivo rodent models of a-synuclein pathology.